9 sachets*5 boxes. Chuanxinlianneizhi Diwan for sore throat due to upper respiratory tract infection. Traditional Chinese Medicine.

Chuanxinlian Neizhi Diwan
Andrographolide Dripping Pills
Chuan Xin Lian Nei Zhi Di Wan
Chuanxinlianneizhi Dripping Pills

FUNCTION and INDICATIONS
For sore throat due to upper respiratory tract infection with wind and heat syndrome.

Traditional Chinese Medicine Functions
Clearing away heat toxic materials, antibacterial and anti-inflammatory.

INGREDIENTS
Andrographolide. Excipients are: polyethylene glycol, film coating premix.

DESCPRIPTION
This product is yellow coated dripping pills, which is white after removal of the coating; bitter taste.

SPECIFICATION AND PACKAGE
0.15g*9 sachets/box.

USAGE AND DOSAGE
For oral use after meals,1 sachet thrice daily or by medical ordor.

REFERENCES

ADVERSE REACTION
Uncertainty.

CONTRAINDICATIONS
Contraindicated in patients who are allergic to this product.

Warning
1.Avoid alcohol and tobacco and spicy,see food during taking this product.
2.It’s not appropriate to take nourishing chinese medicine wihle taking medicine.
3. Pregnant women should be used with caution and children should be taken under the guidance of a physician.
4. Spleen and stomach deficiency cold with diarrhea patients should be used with caution.
5.Three days without any remission,or symptems aggravated,appeared new serious symptems, should go to hospital.
6.Hypersensitivity to this product should stop using，allergic constitution with caution.
7.Do not use this product if the property changed.
8.Children should take under the supervision of adult.
9.Keep out of reach of children.
10.If you are using other drugs, please consult your doctor before using this product.

DRUG INTERACTION
If use with the other drugs at the same time may occur drug interactions,details please consult your physician or pharmacist.

PHARMACOLOGIC ACTION

Pharmacological effects of andrographolide:
1.Anti-pathogenic microorganism action
Animal experiments showed that andrographolide and neoandrographolide inhibited and delayed the increase of body temperature caused by pneumococci or hemolytic streptococcus, but the effect of andrographolide was stronger than that of new andrographolide.
In vitro experiments have shown that andrographolide has a certain anti-HIV effect.
2. Antipyretic effect
Andrographolide tablets have different degrees of antipyretic effects on endotoxin fever, pneumococci or hemolytic streptococcus fever in rabbits. The antipyretic effects of andrographolide, B, C and D on the fever-induced rabbits caused by typhoid fever and paratyphoid vaccine or the fever-induced white rats induced by 2,4-dinitrophenol were weakened.
3. Anti-inflammatory effect
Andrographolide, B, C and D have different degrees of anti-inflammatory effects. 1g/kg can inhibit the increase of skin or abdominal capillary permeability induced by xylene or acetic acid, and reduce the croton oil in Selye granules. The amount of acute exudate was caused, but had no significant effect on granulation tissue proliferation. It can inhibit the development of foot swelling in egg white rats, but the effect disappears after excision of the adrenal gland. The anti-inflammatory effect of Dingsu is the strongest, followed by C, A and B.
4. Impact on immune function
It has been reported that andrographolide tablets may have an effect on certain aspects of cellular immunity. Its decoction can enhance the ability of human leukocytes to phagocytose Staphylococcus aureus in vitro. Oral andrographis can enhance the skin-suspended hypersensitivity reaction caused by old tuberculin. Andrographis preparation Xinyanping (containing esters and ketones) can increase serum lysozyme levels and enhance the phagocytic capacity of peritoneal macrophages and neutrophils. Continuous administration of andrographolide sulfonate to rabbits or mice can significantly increase the phagocytic ability of peripheral blood phagocytic cells against pneumococci or Staphylococcus aureus. Andrographolidine injection and hiyanping injection can also enhance phagocytic function. . Dehydrated andrographolide succinic acid half ester also inhibited delayed-type hypersensitivity in mice induced by 2,4-dinitrochlorobenzene.
5 anti-fertility
Andrographis paniculata has a significant effect of stopping pregnancy. Oral administration of Andrographis can make mice contraceptive and pregnant rabbits aborted. The intraperitoneal injection of decoction has a significant stopping effect on different implantation periods, such as implantation, early pregnancy, middle pregnancy and late pregnancy. Intramuscular injection, subcutaneous injection, irrigation, intraperitoneal injection, intravenous injection and intrauterine injection can produce anti-early pregnancy effects, among which abdominal cavity, vein and intrauterine injection have the best effect. Intrauterine injection, the amount is small, the effect is good. If exogenous progesterone or luteinizing hormone is released and hormone (LH-RH) is injected simultaneously with andrographis paniculata, abortion can be prevented. This suggests that Andrographis paniculata may have an effect against progesterone in the body, causing miscarriage. Some people think that Andrographis paniculata has a certain inhibitory effect on the growth of placental villus trophoblast cells cultured in vitro. Studies have shown that some semi-synthetic derivatives of andrographolide also have different degrees of anti-pregnancy effects. Dehydrated andrographolide derivatives-pepper-4 have good anti-early pregnancy effects on mice and rats, which is worthy of further study. A new contraceptive drug, which has a significant effect on placental trophoblast cells, can cause placental villi atrophy, cell number reduction, syncytium cells and Langham cells disappear, interstitial edema and hemorrhage.
6. Lithium and liver protection
Andrographis paniculata has a beneficial effect on rats, and can increase the liver weight of rats and shorten the sleep time caused by sodium hexabarbital. Pre-administration of andrographolide can counteract the hepatotoxic effects caused by carbon tetrachloride, D-galactosamine and acetaminophen, and can significantly reduce the levels of SGPT, SGOT, SALP and HTG, respectively. It has been reported that the methanol extract of Andrographis paniculata is toxic and can promote the death of rats with liver injury.
7. Anti-tumor effect
Dehydrated andrographolide succinic acid half ester has a certain inhibitory effect on W256 transplanted tumor. Dehydrated andrographolide disuccinate half-potassium hydrogenate is used to make arginine double salt (referred to as succinate), which can inhibit the tumor cells in large, medium and small doses, and the effect is enhanced with the increase of dose. The anti-tumor effect is indeed and stable. In vitro experiments have shown that Andrographis paniculata has an inhibitory effect on DNA synthesis in cultured breast cancer cells.
8. Other effects
Yanhuning and Chuanhuning injection have obvious sedative effect, which can shorten the incubation period of pentobarbital sodium on mice anesthesia, prolong the anesthesia time, and cause anesthesia with subthreshold sodium pentobarbital.
Andrographolide can increase the function of adrenal cortex. The penetramine, B, C and butyl can atrophy the thymus of young mice at higher doses.

STORAGE
Hermetically sealed,keep in cool and dry places.

PERIOD OF VALIDITY
36 months.

CERTIFICATE NO
Stage Food and Drug Administration Approval number:Z20040078.

Manufactured
TIANSHILI MEDICINE GROUP PHARMACEUTICAL CO.,LTD

Tips: Please read the directions for use in retail or directed by physician.
Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive.

General Cautions
Keep away from animals and children.This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health.